Bo Hønge 2018
|Hønge, Bo Langhoff. 2018. HIV-1, HIV-2, and HIV-1/2 dual infections in Guinea-Bissau, West Africa: HIV type discrimination and immunological differences. Bandim Health Project, INDEPTH Network, Guinea-Bissau. Health Aarhus University, Department of Clinical Immunology, Aarhus University Hospital. 71 p.|
Whereas HIV-1 has spread globally, HIV-2 is mostly circulating in West Africa. It is not fully understood why the majority of patients infected with HIV-2 have slower disease progression than for those with HIV-1 infection, or whether HIV-2 induced immunodeficiency differs from that caused by HIV-1. Also, it has been hypothesized that HIV-1/2 dually infected individuals have a disease course that is slower than for HIV-1 mono-infection. Differences in HIV diseaseprogression may be associated with certain immunological characteristics. To be able to investigate these potential immunological differences between HIV-1, HIV-2 and HIV-1/2 dual infections, correct HIV typing and optimal handling of peripheral blood mononuclear cells (PBMCs) are imperative.
The main findings were: