Vision on further studies of NSE

Researchers from Bandim Health Project reveal their vision

In this new methodological and almost philosophical paper, researchers from Bandim Health Project outline their vision regarding how non-specific effects (NSEs) of vaccines can be further studied. Using measles vaccine and oral polio vaccine as examples, the researchers conclude that using randomized controlled trials alone to evaluate NSEs severely limits the possibilities for studying NSEs. Results from both randomized and non-randomized studies should be triangulated to strengthen causal interpretation. Doing that, the researchers build a very strong case for beneficial NSEs of both measles vaccine and oral polio vaccine – these vaccines seem to save far more lives than they should, based on their specific effects alone!

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