SAGE Review

23 January 2013

SAGE Review on the evidence concerning the possible non-specific effects of vaccines

WHO’s Strategic Advisory Group of Experts (SAGE) has requested the WHO Secretariat to review the evidence concerning the possible non-specific effects of vaccines included in the routine infant immunization schedule.

Preparatory to such a review of the evidence by SAGE in 2013, it is necessary to:

  • systematically review all published and grey literature concerning epidemiological studies addressing 'non-specific' effects of BCG, measles and, DTP-containing vaccines on survival/all-cause mortality in children under five years of age and
  • critically appraise the evidence using the WHO Strategic Advisory Group of Experts (SAGE) guidelines.

A Working Group will be established and asked to determine if the current evidence is sufficient to lead to adjustments in policy recommendations or to warrant further scientific investigation, and if so, to define the path towards obtaining unequivocal evidence on these issues that would support future robust, evidence-based adjustments in immunization policies, if warranted.

Read moreCall for nominations for SAGE Working Group on non-specific effects of vaccines

Last revised 23 January 2013

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